Prednisolone is a corticosteroid used to treat certain types of allergies, inflammation, autoimmune diseases, and cancer. Can treat symptoms such as adrenocortical Insufficiency, high blood calcium, rheumatoid arthritis, dermatitis, eye inflammation, asthma and multiple sclerosis. This product can be used orally and intravenously, or as a skin cream and eye drops.
pharmacology
As a glucocorticoid, prednisolone's lipophilic structure makes it easy to cross the cell membrane and then bind to its respective glucocorticoid receptor (GCR) located in the cytoplasm. After binding, the formation of the GC/GCR complex leads to dissociation of the molecular chaperone from the glucocorticoid receptor, causing the GC/GCR complex to shift in the nucleus. This happens within 20 minutes of binding. Once in the nucleus, the protein dimer GC/GCR complex binds to specific DNA binding called glucocorticoid response elements (GREs), resulting in gene expression or inhibition. The combination of positive response elements (GREs) with negative response elements (GREs) leads to the synthesis of anti-inflammatory proteins, which block transcription of inflammatory genes.
Chemical properties
Prednisolone is a corticosteroid of a progesterone organic compound that is closely related to its homologous prednisone and has the same structure except for the saving of two hydrogen molecules near C11. It is also known as δ 1-cortisol, δ 1-hydroprednisone, dehydrocortisol 1 and 2, dehydrocortisol 1 and 2, or dehydrocortisol 1 and 2.
Side effects
Short-term side effects of prednisolone include nausea and fatigue, while more serious side effects are psychosis related problems, which occur in about 5 percent of 100 people. Common side effects of long-term use include osteoporosis, weakness, candidiasis, and bruising. Although short-term use is safe in late pregnancy, early use or prolonged use in late pregnancy may harm the baby. Prednisolone is a glucocorticoid made from hydrohydrocortisone.
