The ratio of HCG (Human Chorionic Gonadotropin) lyophilized powder usually depends on the specific drug brand and purpose (such as fertility treatment, hormone regulation, etc.). Generally speaking, the standard ratio of **5000 IU HCG lyophilized powder** is as follows:
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### **1. Standard ratio (taking common drugs as an example)**
- **HCG lyophilized powder: 5000 IU**
- **Diluent (solvent): usually 1 mL sterile water for injection (or saline)**
- For example: Pregnyl® (Pfizer), Ovidrel® (Merck) and other brands all use similar ratios.
- Some drugs may come with **1 mL or 2 mL solvent**, please refer to the instructions for details.
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### **2. Common dilution methods**
- **5000 IU + 1 mL solvent** → **concentration is 5000 IU/mL**
- Suitable for single injection of full dose (such as triggering ovulation in fertility treatment).
- **5000 IU + 2 mL solvent** → **concentration is 2500 IU/mL**
- Convenient for multiple injections (such as 500-1000 IU per injection in male hormone therapy).
> **Note**: The actual ratio should be based on the drug instructions, and different brands may vary slightly.
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### **3. Excipient ingredients (may be included in lyophilized powder)**
In addition to the active ingredient, HCG lyophilized powder usually contains the following stabilizers:
- **Mannitol**: as a lyophilization protectant.
- **Sodium phosphate buffer**: adjust pH (about 6.5-7.5).
- **Other**: Some brands may add lactose or gelatin.
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### **4. Precautions for use**
1. **Strict aseptic operation**: Disinfect the rubber stoppers of the medicine bottle and solvent bottle with alcohol before use.
2. **Dissolution method**: Slowly inject the solvent into the freeze-dried powder bottle and gently rotate (do not shake violently) until completely dissolved.
3. **Storage conditions**:
- Undissolved freeze-dried powder: **Refrigerate at 2-8°C** (avoid freezing).
- After dissolution: It is recommended to use **within 24 hours** and refrigerate (some brands allow 48 hours).
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### **5. Frequently Asked Questions**
- **Can physiological saline be used instead of the accompanying solvent? **
If there is no special solvent, sterile water for injection can be used (physiological saline needs to confirm compatibility with the drug).
- **Dose adjustment**: If you need to use it in divided doses, it is recommended to consult a doctor to avoid multiple dissolutions affecting the efficacy of the drug.
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### **Summary**
The standard **5000 IU HCG lyophilized powder** has a ratio of **1 mL solvent/bottle**, but the specific ratio should be based on the drug instructions. Pay attention to aseptic operation and storage conditions when using to ensure efficacy and safety.
