Lyophilized powder formulations of Tirzepatide are usually in the form of **acetic acid** (acetic acid) rather than hydrochloric acid. The following is a detailed description:
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### **1. Common acid forms of Tirzepatide**
- **Tirzepatide Acetate**
Currently marketed Tirzepatide (such as Eli Lilly's **Mounjaro®** or **Zepbound®**) all use **acetic acid** as a stabilizer and pH adjuster. Acetic acid can maintain the solubility and stability of the drug in the lyophilized powder and reduce the degradation of peptide drugs.
- **Tirzepatide Hydrochloride? **
**No** official drugs or authoritative literature mentions the hydrochloride form of Tirzepatide. Hydrochloric acid may affect the structure and biological activity of peptide drugs and is therefore not used in legal formulations of GLP-1/GIP receptor agonists (such as Tirzepatide).
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### **2. Excipients and acid types of lyophilized powder**
- **Role of acetic acid**
- Adjust pH (usually 4.0-5.0) to ensure drug stability before and after lyophilization.
- Prevent peptide aggregation or denaturation, especially during long-term storage.
- **Possibility of other acids**
In theory, other weak acids (such as citric acid) may be used in some peptide preparations, but only acetic acid is used in approved products of tesiparatide.
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### **3. Precautions**
- **Formulation of legal drugs**
The lyophilized powder or prefilled pen preparations of tesiparatide (such as Mounjaro®) on the market clearly use **acetic acid**, and excipients may include mannitol, sodium phosphate, etc.
- **Risks of informal sources**
If you encounter a lyophilized powder labeled "tesiparatide hydrochloride" (especially research-grade or non-patented products), you need to carefully verify its source and purity, because there is a lack of clinical safety data for the hydrochloride form.
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### **4. Summary**
The legal preparations of tesiparatide lyophilized powder are **tesiparatide acetate**, and there is currently no approved product in the form of hydrochloride. When choosing a drug, it is recommended to give priority to the approved preparations from formal channels and refer to the excipient information in the instructions.
