Semaglutide lyophilized powder may use different acids as stabilizers or excipients for pH adjustment in different formulations, but usually acetic acid (acetic acid) is the main acid rather than hydrochloric acid. The following is a detailed description:
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### 1. **Common acid forms of semaglutide**
- **Semaglutide Acetate**:
This is the most commonly used form of semaglutide lyophilized powder (such as injection formulations). Acetic acid is used to maintain the solubility and stability of the drug, especially during the freeze-drying process. For example, Ozempic (semaglutide injection) produced by Novo Nordisk uses an acetate buffer system.
- **Semaglutide hydrochloride**:
Currently, **no** authoritative literature or drug instructions mention the hydrochloride form of semaglutide. Hydrochloric acid may affect the stability or biological activity of peptide drugs, so it is generally not used for this type of GLP-1 receptor agonist.
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### 2. **Differences in acid types of lyophilized powder**
- **Role of acetic acid**:
In lyophilized preparations, acetic acid (acetic acid) is often used to adjust the pH (usually in the range of 4.0-5.0) to ensure the stability of semaglutide in liquid and solid states and reduce aggregation or degradation.
- **Possibility of other acids**:
In theory, other weak acids (such as citric acid) may also be used in the preparation of peptide drugs, but hydrochloric acid has not been reported in clinical and commercial products of semaglutide.
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### 3. **Precautions**
- **Source of drug**:
Commercially available semaglutide lyophilized powder (such as Ozempic or Rybelsus injection) clearly uses acetic acid and must be obtained through formal channels to avoid the use of "laboratory customized" products of unknown origin.
- **Non-patent issues**:
Some generic or research-grade lyophilized powders may be labeled with different excipients, but the hydrochloride form lacks clinical data support and needs to be carefully verified.
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### 4. **Summary**
Legal preparations of semaglutide lyophilized powder are usually **semaglutide acetate**, and there is no approved product in the form of hydrochloride. If you encounter lyophilized powder labeled "semaglutide hydrochloride", it is recommended to verify its source and excipient description, or consult a medical professional.
If you have further questions (such as the specific formulation formula), it is recommended to refer to the drug instructions or contact the pharmaceutical company for confirmation.
