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Home / Knowledge / Content

Melanotan 2 : Peptide Guide

Apr 19, 2022

How to Use M2

Melanotan II analog of alpha-melanocyte stimulating hormone (a-MSH). Melanotan peptides are safe and efficacious with growing long term data. Melanotan 2 is a freeze dried peptide sealed in a sterile multi-use vial. Tanning injections of synthetic potent a-MSH allow for development of photo-protective suntans in all skin types.

Melanotan 2 Dosage

 Range: 100mcg - 1mg


Melanotan II Side Effects

Melanotan injections act on melanocytes to stimulate melanin production. Melanin is the body's pigment responsible for a photoprotective safe tan.
Melanin skin tanning after Melanotan injection

Sunless tanning injections begin with the peptide sequence: His-Phe-Arg-Trp. Melanotan peptides Melanotan II binds to melanocortin receptors influencing pigmentation, inflammation, energy, appetite and sexual function. Melanotan 2 has a small protective amino acid structure that effects the melanocortin 1, 3, 4 and 5 receptors.

Melanotan 2 Peptide Hormone

Melanotan 2 is a small efficient molecule as compared to the linear original Melanotan I design after natural melanocyte stimulating hormone peptide. Melanotan is approximately 1,000 times more potent than natural a-MSH. Melanotan half life of minutes, Melanotan 2 half life ~1 hour.
melanotan results

Folks who never tan, always burn in the sun, can achieve a natural tan when using Melanotan II. For people with sun allergies/mutated receptors, synthetic melanotropin peptide supplements offer life changing opportunity. A natural tan developed over time is the best defense against cancer, to which the fair skin can now acheive. Melanotan was designed to reduce cancer rates and potentially become effective as a sunless tanning agent.


Mixing Melanotan 2: 1-2ml Bacteriostatic water reconstitutes and preserves tanning peptide Melanotan best. Dilute with more volume for improved dosing accuracy (micrograms).

Dosage Calculator: Add 100 units (1ml) of water to the vial. 1ml Bacteriostatic water will minimize injection volume and simplify arithmetic. Dosing measurements are often mentioned in both milligram (mg) and microgram (mcg).
1ml syringe (U100), 1ml Bac Water to Reconstitute
Calculations for .5mg or 500mcg dose:
Step Dosage
Step 1 1ml
Step 2 10mg Melanotan II
Step 3 1ml Bacteriostatic Water
Step 4 500mcg Dose
5 units on your insulin syringe (approximately 1/20th of a U100 syringe).
peptide calculator

Needles: 29-31 gauge X 1/2", 1 CC (100 unit). That is a typical insulin needle used to mix as well as inject. Use needles one time only. Once your technique perfected, injections are almost painless. Smaller 1/2 and 1/3cc syringes offer greater measurement accuracy and pre-loading convenience.

Melanotan Dosage: Your first injection should be a very small dose, for example .25mg (250mcg). See how you react. Goal should be to feel nothing. Dose after dinner, before bed. Any dosing chart stating that you should take a high dose (according to your weight) is dated and potentially dangerous.

Loading dose: Load with .5-1mg once a day. People who have used doses in this range generally report getting excellent results. Don't worry if you miss occasional days. It will not make much difference, focus on the cumulative effects. A tan generally sets in 3 days after UV rays. Dose and expose yourself gradually to UVR when tanning.

Maintenance dosing: Maintenance is taking doses less frequently than daily to avoid becoming darker than you want. Yes, that will happen. With enough UVR, you will get much darker than you have even been before. A maintenance dose can help prolong super-physiological photo-protection MT-2 delivers.



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