HOW DOES human growth hormone - somatropin - DO ITS WORK?

Human growth hormone - somatropin - is short lived, but during its short half-hour or so activity per burst from the pituitary, it exerts itself through direct and indirect effects.

Its direct effects are the result of the human growth hormone - somatropin - binding its receptor on target cells. Fat cells (adipocytes) as well as myocytes (muscle cells) have human growth hormone - somatropin - receptors. On fat cells, human growth hormone - somatropin - stimulates them to break down triglyceride and suppresses the fat cells ability to uptake circulating lipids.

Its indirect effects are in the process we described in the section above. When human growth hormone - somatropin - travels to the liver, one of the results of its pass through the liver is the livers secretion of IGF-1. When this IGF-1 is secreted, it stimulates proliferation of chondrocytes (cartilage cells), which result in bone growth. It also plays a part in stimulating both the proliferation and differentiation of myoblasts (the precursor to skeletal muscle fibers). IGF-1 also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Other tissues (muscle, etc.) are acted on by the presence of human growth hormone - somatropin - , also inducing their release of IGF-1.

human growth hormone - somatropin - stimulates protein anabolism in many tissues. This reflects increased protein synthesis, decreased oxidation of proteins, and increased amino acid uptake. As mentioned above, human growth hormone - somatropin - enhances fat utilization by stimulating triglyceride breakdown and oxidation in fat cells (adipocytes).


human growth hormone - somatropin - can affect the function of other hormones. human growth hormone - somatropin - can suppress the abilities of insulin to stimulate the uptake of glucose in tissues and enhance glucose synthesis in the liver, though administering human growth hormone - somatropin - actually stimulates insulin secretion and can create a state of hyperinsulinemia. This combination can lead to decreased insulin sensitivity, which in turn can lead to hyperglycemia. human growth hormone - somatropin - can in the right cirstances also have a slight inhibitory effect on the function of our thyroid hormones (and actually vice versa as well), though this varies greatly from individual to individual. The vast majority of users have no need to worry about this at all. Others wishing to increase their metabolism or enhance certain of human growth hormone - somatropin - ’s functions may wish to consider low dose thyroid to their human growth hormone - somatropin - cycle. We’ll offer some strategies later in this guide.

So, we are looking at a hormone that can assist with maintenance and healing of most of the body’s systems, can create new cartilage, bone, and muscle cells, can assist with protein uptake, decrease the oxidation of proteins, and can accelerate the rate at which fat is utilized. This paints the picture of the excitement that follows human growth hormone - somatropin - . How then do we utilize this to our advantage? Let’s take a look at some strategies.