Dexketoprofen Trometamol Cas:156604-79-4

Overview:
D-ketoprofen tramine is a novel antipyretic, analgesic and anti-inflammatory drug with relatively few side effects, which can be used to treat mild to moderate pain.

Synthesis method: Anhydrous ethanol, ethyl acetate and trobuprofen were added to D-ketoprofen respectively, the weight ratio of which was D-ketoprofen: anhydrous ethanol: ethyl acetate: trobuprofen = 1:2:7:0.48, stirred, reflux for 30 minutes, filtered to crystallization tank while hot, cooled with condensed water to 28-32 ° C, and cooled to less than 10 ° C for 3 hours, then centrifuged The filter cake was washed with a mixed solution of 1 weight part anhydrous ethanol and 7 weight part ethyl acetate for 2 times, centrifuged, distilled filtrate for recovery, dried at 50℃ for 10 hours, and crushed to obtain D-ketoprofen tramine finished product.