Background and Overview
Medical glycerol, or 1,2, 3-glycerol, is found in complex forms in vegetable and animal oils and fats, in the form of triglycerides combined with fatty acids such as stearic, oleic, palmitic, and lauryl acids. From plant and animal oils and fats in involving industrial methods of glycerol saponification reaction, high pressure hydrolysis reaction and the ester exchange reaction of alcohols such as ethanol and methanol, glycerin, including a variety of impurities, which involves numerous and complicated processing steps, glycerin is widely use, especially the high purity of high quality natural biological pharmaceutical grade, As new uses are developed and emerging, the market is bound to be in short supply
Preparation technology
The invention relates to a purification method for pharmaceutical glycerin, which includes the following steps:
S1. Grind Muscovite and add barium nitrate solution to mix and stir. Adjust the pH value of the system to 5.5 ~ 6.5 with hydrochloric acid.
S2, will warm up sepiolite powder, thermal insulation, cooling to room temperature, to join the hydrochloric acid, temperature mixing, filtering and washing to show in sex, dry, add furfural mixing, heating, heat preservation, heating up under nitrogen protection, thermal insulation, cooling, washing to neutral, stir in pretreatment white mica, drying, crushing get sepiolite stone white mica composites;
S3. Add water to crude glycerol and sepiolite Muscovite complex, stir and stand; Decompression filtration, filtrate through the water washed 001×7 type cation exchange resin column, and then through 201×7 type anion exchange resin column, rotary evaporation, temperature evaporation until the distillation of the free liquid, continue to pump air; The distillates at 152 ~ 158℃ were collected in the distillation column and sent to the deodorization column for deodorization and heat exchange. Then the distillates were sent to the decolorization column for decolorization to obtain glycerol for medical grade.
Use
1,
The invention relates to a preparation method of glycerol phosphoric acid, using medical glycerol and food-grade phosphoric acid as raw materials, and the ratio (mole ratio) of the two is: glycerol: phosphoric acid ≤1.0; The reaction temperature was 120℃ -- 150℃, the reaction pressure was vacuum, and the reaction time was 4 -- 7 hours. The solution after the reaction was cooled, hydrolyzed with non-ionic water, and then decolorized with grade activated carbon with sugar, and then filtered and packaged. The invention has simple process and high conversion rate of raw materials.
2,
A method of synthesis of calcium glycerophosphate made raw materials, pharmaceutical glycerine and food grade phosphoric acid for esterification reaction in the reaction kettle, after the reaction, the reaction of cool solution, then add deionized water dilution, and through active carbon decoloring, add a certain amount of calcium hydroxide, after ultrasonic stirring reaction, to filter the reactants, clarify the filtrate, to filtrate zhongtong into CO2, Keep the filtrate pH at 8-10, then filter. Then add alcohol to filtrate, stir, spray drying, white powder is the product. The invention has simple process and low cost; The quality of the synthesized calcium glycerophosphate is stable and meets the standard of European Pharmacopoeia 63 edition.
3,
CN201510880617.1 discloses selenium disulfide ultrafine powder and its preparation method, which belongs to the field of detergent. The invention solves the quality problems of selenium disulfide ultrafine powder prepared by medium ball milling micropowder as a detergent, such as long production time, large selenium disulfide particles, uneven dispersion and instability. The particle size of selenium disulfide ultrafine powder in the invention is (1~50)μm. The method of the invention is as follows: 1. Mix selenium disulfide dry powder, purified water, pharmaceutical titanium dioxide and pharmaceutical glycerin evenly, and then add citric acid to adjust pH value between 3.5 and 4.5; 2. Two, and then placed in grinding type ultrafine mill grinding and grinding, so as to obtain selenium disulfide ultrafine powder. The selenium disulfide ultrafine powder can be applied to lotion, shampoo, hair conditioner and other daily chemical products.
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