Sibutramine hydrochloride (tramex) is indicated for the treatment of obesity in patients who cannot lose weight through diet control and exercise control, including weight loss and maintenance of weight loss. Treatment should be combined with low calorie and exercise. Sibutramine hydrochloride is recommended for the treatment of body mass index of 30kg/m2 or 27kg/m2(with other risk factors such as hypertension and diabetes) The larger the obesity base is, the more obvious the weight loss effect is.
Adults taking sibutramine for 1 year are 19% to 34% more likely to achieve 5% weight loss and 12% to 31% more likely to achieve 10% weight loss than those taking placebo.
