Hubei YYD Industrial Co., Ltd.

The Use And Preparation Of Methoxyacetic Acid

Jul 13, 2022

Methoxyacetic acid is an organic compound with chemical formula C3H6O3. This compound is both a carboxylic acid and an ether and is a derivative of acetic acid. A colorless liquid having a distinctive odor. The substance may form explosive peroxide. Reacts with a strong oxidizer and base.

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Use

Methoxyacetic acid is an important organic chemical raw material, it and methanol through the esterification reaction to synthesize methyl methoxyacetic acid has important value intermediate, the intermediate can not only be used for the kinetic resolution of chiral amines, but also for the synthesis of vitamin B6, sulfa-5-pyrimidine, etc. In addition, methoxyacetic acid can also be used to prepare methoxyacetyl chloride, which has important uses in plant protection and the pharmaceutical industry. At present, methoxyacetic acid is mainly prepared by substitution reaction and oxidation reaction.


The preparation methods

Methoxylacetic acid can be obtained by the oxidation of methoxylethanol.

The invention discloses a method for preparing methoxyacetic acid, in which 5% Pt/C by mass percentage is used as catalyst, oxygen is used as oxidant, and water is used as solvent. Methoxyacetic acid is prepared by one-step oxidation of ethylene glycol monomethyl ether.


Exposure and health effects

The contact way

The substance can be absorbed into the body by inhalation of its vapor, through the skin, and by ingestion.


Effects of short-term exposure

The steam slightly irritates the eyes. The substance may affect bone marrow and the central nervous system. High concentrations can affect the blood. Can lead to blood cell damage and kidney damage. Exposure well above occupational exposure limits can cause unconsciousness.


Effects of long-term or repeated exposure

The substance degreases the skin and causes dryness or chapping. The substance may affect bone marrow and blood. Can lead to blood cell damage and kidney damage. May cause human reproductive or developmental toxicity.


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