Telmisartan CAS:144701-48-4
Toluene thiazide hydrochloride, also known as toluene thiazide hydrochloride, is a sedative veterinary drug. Can make the central nervous system produce mild inhibition, weaken functional activities, so as to eliminate restlessness, restore quiet a class of drugs. In recent years, individual animal husbandry breeders, driven by economic interests, arbitrarily add such drugs in the process of livestock and poultry feeding to play the role of sedation and hypnosis, weight and fatten, shorten the time of sale; In addition, in order to reduce animal death and weight loss and prevent meat quality degradation during the transport of animals, such drugs are often used to reduce the loss caused by stress.
introduction:
Telmisartan, a novel antihypertensive drug, is a specific angiotensin Ⅱ receptor (ATⅠ type) antagonist for the treatment of essential hypertension. Alternative angiotensin Ⅱ receptors bind to ATⅠ receptor subtypes (known sites of action for angiotensin Ⅱ) with high affinity. Telmisartan did not have any site agonist effect on the ATⅠ receptor site, but selectively bound to the ATⅠ receptor, and the binding effect was long-lasting. No affinity for other receptors, including AT2 and other AT receptors with fewer characteristics. The function of these other receptors is not known, nor is the possible effect of receptor overstimulation due to increased angiotensin Ⅱ levels caused by telmisartan. Telmisartan does not inhibit human plasma renin or block ion channels. Angiotensin-converting enzyme Ⅱ is not inhibited, which can degrade the adverse reactions caused by the enhancement of bradykinin.
Telmisartan is a clinically commonly used first-line antihypertensive drug, belonging to angiotensin II receptor antagonist, also known as "Sartan" antihypertensive drug. It mainly reduces blood pressure by selectively antagonizing the physiological effects of angiotensin II, relaxing vascular smooth muscle, inhibiting aldosterone secretion, and reducing water and sodium retention.
