GS-441524 Cas:1191237-69-0 For Cat

Feline infectious peritonitis (FIP) is a devastating and almost always fatal feline disease that results from mutations in the common feline coronavirus (FECV), which infects 40-80% of cats worldwide. GS-441524, also known as GS-5734, is an effective inhibitor of feline infectious peritonitis (FIP) virus. GS-441524 showed strong inhibition against feline infectious peritonitis (FChemicalbookIP) virus. GS-441524 is a molecular precursor of pharmacologically active nucleoside triphosphate molecules. These analogues can be used as alternative substrates for viral RNA-dependent RNA polymerase and as RNA strand terminators. GS-441524 has a non-toxic concentration of up to 100 in feline cells, effectively inhibits FIPV replication of CRFK cell culture and a concentration of peritoneal macrophages as low as 1 in naturally infected cats.

Use: GS-441524 is a small molecule known as a competitive inhibitor of nucleoside triphosphate, which shows strong antiviral activity against many RNA viruses. It can inhibit the replication of several different types of RNA viruses, such as zoonotic severe Chemicalbook acute Respiratory Syndrome (SARS) coronavirus, Middle East Respiratory syndrome virus, Ebola virus, Lassa fever virus, Junin virus and respiratory syncytial virus, while having low cytotoxicity in a wide range of cell lines.

What is GS-441524? GS-441524 is the second targeted antiviral agent for the treatment of feline infectious peritonitis (FIP) after GC376. GS-441524 is a small molecule nucleotide analogue provided by GileadSciences(NO.1 in the global antiviral field) to UCDaviChemicalbooks (NO.1 in the global veterinary field) PerdersenNCjiaoshou2 and its research topic of abdominal transmission. It is a reverse transcriptase inhibitor that can inhibit the replication of feline ventral virus (FIP). It is a prerequisite molecule for the synthesis of nucleoside triphosphate with pharmacological activity.

Mechanism of action GS-441524 is phosphorylated to nucleoside monophosphate (NMP) by cellular kinase in the cell and then converted to an active triphosphate metabolite (NTP structural analogue). In viral RNA synthesis, active NTP structural analogs filled with Chemicalbook compete with natural nucleosides (ATP, TTP, CTP, GTP) to participate in RNA transcription. When GS-441524 molecule is inserted into the transcription product, transcription will be terminated in advance, thus suppressing the viral RNA transcription process.