HGH

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Clinical trials using synthetic human growth hormone began in the early 1980’s. By 1985, recombinant human growth hormone became available commercially. One of the first certified products in the USA in those years was Protropin‚ by Genentech Inc. This product differs from more popular hGH remedies of today like Jintropin, Somatorm, and Humatrope, in that it contains somatrem instead of somatropin. Somatrem is a synthetic hGH protein that contains an additional methionine amino acid, which has been added to the 24-amino acid initiation sequence. Natural (endogenous) human growth hormone is a polypeptide containing 191 amino acids. The biosynthetic process used to make somatrem, also called the Inclusion Body Process, involves the chemical synthesis of the DNA fragment encoding the first 24 amino acids. The remaining amino acid residues are obtained by making complimentary DNA copies of messenger RNA prepared from human pituitary cells. The entire DNA sequence is introduced into a bacterium, Escherichia coli (E.coli),which is then able to synthesize the hGH protein.

Somatrem, known chemically as MethGH or N-methionyl-hGH, was first believed to be equal to endogenous growth hormone (with 191 amino acids) in all regards. That was perhaps only because they compared it to biological (corpse) growth hormone, which was not pure, and contained pollutants that produced side effects in many users. This led to allergic reactions, and sometimes the antibodies are so prominent that they even neutralized the effect of the administered hormone. Antibodies were noted in approximately 50% of the young users in one clinical experiment, and a second British experiment rated the response even higher, in 80% of users. 

A new phenomenon seems to be informative research websites regarding human growth hormone. These websites often come from the Chinese manufacturers, for examplewww.hgh-research.com andwww.somatropin.net. It appears that a group of Chinese manufacturers of growth hormone actually launched the latter website. This website wants “to inform users and oppose abuse of growth hormone”, accord-ing to a press message. But the website is in reality an ingenious marketing-instrument of GeneScience, the manufacturer of the growth hormone brand Jintropin. The press message that announced the launch of somatropin.net is surprisingly honest about who are the most important users of growth hormone. It is not the children with a deficiency of growth hormones,but athletes, bodybuilders, and anti-agers.

A vial Blue Tops growth hormone compound was analysed through Ergogenics in January 2010. It did not contain growth hormone,but a substance that caused violent pain after the injection. The reason became clear after analysis by an accredited laboratory. The scientists first searched in the sample for peptide pieces between 5 and the 220 kilo daltons. Because they did not find any, that excluded that the ampoule contained the correct 4 iu of GH. This analysis took place using SDS-PAGE and LC-MS. Because the owner of the compound had got violent pain after injection, the scientists searched in the ampoule further for toxicological substances.

With Hplc-DAD method they found out that the ampoule contained a thiamine derivate, which at closer research with LC-MS proved to be thiaminediphosphate, a derivative of the vitamin B1 that is not suitable for injection. The valued quantity was estimated at 25 milligram per ampoule. Because the scientists had performed already some analyses with the ampoule they could not determine the exact quality. That vitamin alternative was produced as a byproduct/contaminant of inclusion body technology, and it was causing injection pain. When dissolved in water thiaminediphosphate reduces pH.

What side effects can you get from hGH use?

There are many possible side effects from hGH use, but most are related to incredibly high doses with prolonged use. Some of the more prominent effects are; swelling of the hands or feet due to edema, acromegaly which is thickening of the bones or jaw, carpal tunnel syndrome, numbness in the extremities of hands and fingers, and increased organ growth. 

More common side effects that are of concern to bodybuilders are decreased insulin reception and sensitivity, and decreased thyroid output. 

I am a drug tested athlete, will hGH show up?
For this question I will defer to the IOC (International Olympic Committee) which is also happens to be the same procedure for NCAA athletes:
Main applicable detection techniques are based on immunoanalysis which may involve a relative lack of antibody specificity and therefore extensive cross reactivities with other compounds. In some cases there do not exist suitable internationally acceptable reference materials in order to fully homogenise results obtained by different techniques in different laboratories. As a consequence, quantitative concentrations found in a given laboratory are difficult to compare with those found in other settings. It is always difficult to establish clear criteria to distinguish an exogenous administration (banned) from a normal endogenous concentration (Segura J., 1991). Ideally, the structure of the peptide detected should be confirmed by mass spectrometry. This is difficult nowadays although new ionisation techniques, new interfaces with chromatographic or electrophoretic systems and evolution of ion analysers will make a contribution to this end in the future.

So to sum it up, they still have no reliable testing procedures in place. Because clearance times can be as little as minutes on some peptides, chances are they will not have a reliable test for years to come….so enjoy their use in tested sports for now.

What about all the new peptides, should I use them too?

Their have been a lot of developments in recent years making hGH seem like an old drug. The creation of IGF-1, MGF, GH Fragments, GHRH, and others create quite a bit of confusion in first time growth hormone users. My recommendation is to start with hGH due to the fact that is has been in use for many years, dosages have stable recommendations, and there are numerous tests in human subjects that attest to its safety. None of the new peptides on the market have any reliable testing procedures, have not been approved for human use, and all feedback is anecdotal at best. Future articles will address the new onslaught of peptides and their use in athletes.

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